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Individuals under 18, pregnant or nursing individuals, or those with active medical conditions - per the brand's own label caution, physician consultation is recommended before use in these groups

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Maximum pain-free standing time (Max PfST) and maximum pain-free walking distance (Max PfWD) were recorded at baseline and post-treatment fourth week

The inflammatory cascade still fires

The result is a significant boost in intracellular NAD+ levels, which in turn activates sirtuins (SIRT1) proteins known to regulate cellular health and metabolism