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For instance, certain GLP1R variants correlate with greater weight loss in GLP-1 agonist users, while GIPR variants may indicate stronger response to tirzepatide's GIP arm

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Break of 5 weeks or more (including 3 months): Restart at the lowest dose, 0.25 mg weekly

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SGLT2 inhibitors (sodium-glucose co-transporter-2 inhibitors) represent an excellent alternative class: Medications such as empagliflozin, dapagliflozin, or canagliflozin work by increasing urinary glucose excretion

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GLP-1 receptor agonists mimic a natural hormone your gut produces after eating, one that tells your brain you are full and slows the rate at which food leaves your stomach

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