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Renowned for its ability to replenish levels of the antioxidant glutathione, it also regulates the important neurotransmitter glutamate
In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
Thus, keeping glutathione at optimal levels is critical for healthy aging
Neuropil A dense network of interwoven axons, dendrites, unmyelinated fibres and synaptic connections in the grey matter of the central nervous system, crucial for information processing, neuronal communication and cognition
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