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For eliminating the potential baseline effect of different studies, the rates of body weight change from the initial values were selected as the therapeutic index

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The mass spectrometer was operated in the positive electrospray ionization (ESI) mode, and the MS/MS analysis was performed in the multiple reaction monitoring (MRM) mode, monitoring the transitions of m/z 162.0 103.0 for carnitine, m/z 147.1 88.1 for IS, respectively

- Systemic inflammation and lipotoxicity

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