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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

Jiang, Y., Berry, Daniel, C., Tang, W., Graff & Jonathan, M

[ 4 , 9 ] Regarding cognitive function, a 2025 Phase 2 randomized trial found that while tesamorelin reduced waist circumference, cognitive benefits did not significantly differ between the tesamorelin and control groups

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Ultimately, your supplementation plan should be based on individualized, evidence-based care