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Allosteric activation of SARS-CoV-2 RNA-dependent RNA polymerase by remdesivir triphosphate and other phosphorylated nucleotides

PMID 33189083

ROS increase the severity of bronchial asthma by activating numerous inflammatory mediators, including leukotrienes B4 (55) and D4, regulated on activation, normal T-cell expressed and secreted (RANTES) chemokines, eotaxins, IL-5 (55), IL-1, -4, -6, GM-CSF, interferon (INF), platelet-activating factor (PAF), tumor necrosis factor (TNFa), adhesion molecules (VCAM-1) (56) and major basic protein (MBP) (57)

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