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Despite fewer data are available in PsA patients, short-term studies show a trend toward dose tapering and against treatment discontinuation in patients with well-controlled disease [151], although 55% of PsA patients might remain on remission after anti-TNF- discontinuation [152]
doi: 105
The peptide appears to promote mucosal healing through enhancement of epithelial cell proliferation and migration, restoration of tight junction integrity, and modulation of inflammatory responses within the gastrointestinal tract
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Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity
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