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Researchers believe GIP co-activation may have a protective effect on the GI tract, explaining why dual and triple agonists are often better tolerated than single-agonist Semaglutide (which has 44% nausea rates)

The role of G protein-coupled receptor kinases in GLP-1R -arrestin recruitment and internalisation

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PubMed Central PMCID: PMC12125019

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