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2015;6:e2035e2035

58 A 0.5% concentration of SM produced no clinical evidence of endothelial damage

Research-grade specs Class: Small-molecule NNMT inhibitor (not a peptide) Molecular weight: 177 g/mol Vial size: 50 mg Format: Lyophilized powder Mechanism studied: NNMT inhibition and intracellular NAD availability This compound is manufactured under cGMP conditions in Dallas, Texas, and independently verified to 99% purity through HPLC and mass spectrometry analysis, with a batch-specific Certificate of Analysis provided for every order

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This was supported by Bester et al., who demonstrated that IL-1, IL-6, and IL-8 (proinflammatory cytokines) promote whole-blood hypercoagulability and alter erythrocyte membrane structure