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Subsequent studies have proved that activation of Nrf2 and inhibition of Keap1 lead to SLC7A11 upregulation, thereby promoting resistance to ferroptosis (Fan et al., 2017).The expression of SLC7A11 can also be inhibited by transcription factors such as Tumor protein p53 (p53) and Activating transcription factor 3 (ATF3)

Excess fat tissue increases estrogen levels while reducing testosterone, both of which can impair sperm production

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