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Sep 2007;30(9):775-80

Over time, pharmacological engineering enabled: Short-acting injectables (e.g., exenatide) Long-acting once-weekly injectables (liraglutide, semaglutide) Multi-target incretin therapies (tirzepatide) Oral peptide formulations and now oral small molecules The most recent breakthrough is the development of orally available GLP-1 receptor agonists, including: Orforglipron (Lilly) Elecoglipron (AstraZeneca) These compounds eliminate the need for injection and could dramatically expand accessibility and adherence in obesity and diabetes populations

GLP1s Roles in the Body GLP-1 is an incretin, a hormone that promotes insulin release from the pancreas in response to elevated blood glucose after eating

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We confirm that all methods for these studies were carried out in accordance with relevant guidelines and regulations, and all experimental protocols satisfy the Adelaide University Human Research Ethics Committee criteria as being negligible risk research