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BMJ 348 , g2366 (2014)
This question concerns many patients considering or currently using this GLP-1 receptor agonist for weight management or type 2 diabetes
A 2026 analysis in the Journal of Medical Internet Research found real-world discontinuation rates far exceed clinical trial numbers, with up to 70% of patients stopping treatment within 24 months -- often because of these effects
Holvoet, T
Weight regain typically becomes noticeable within 24 weeks as hunger signals reactivate and portion control becomes harder without the medication's appetite-suppressing effect
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