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2003;284(4):E6718

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[21] The underlying principle, supported by guidelines from the Endocrine Society, American Association of Clinical Endocrinology, and American Gastroenterological Association, is that obesity is a chronic metabolic disease requiring ongoing medical management

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[11] [12] These cardiovascular benefits have influenced treatment algorithms, with guidelines recommending GLP-1 receptor agonists with proven cardiovascular benefit for patients with type 2 diabetes and atherosclerotic cardiovascular disease

The addition of SGLT2 inhibitors could probably improve both short-term weight loss and long-term weight maintenance