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Semaglutide suppresses thirst signals, but dehydration worsens nausea and fatigue

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Since DPP4 is found mainly in the meninges and blood vessels, whereas DPP8 and DPP9 are ubiquitously distributed in the brain, it has been hypothesized that NPY is cleaved to the truncated NPY 3-36 in the periphery by soluble DPP4 or membrane-bound DPP4

Curiously, they also seemed to suppress appetite, and some people taking them lost a modest amount of weight

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