[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency
It does not require encapsulation, a carrier molecule, or special formulation to maintain structural integrity in biological environments
Boeckler, F
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