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Last but not least, it was shown recently that d-ribose drives non-enzymatic glycation of hemoglobin [188], thereby interfering with oxygen loading and unloading [182] and inducing erythrocyte damage and eryptosis [188]

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The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells

In 2022, 2.5 billion adults aged 18 years and older were overweight, including over 890 million adults who are classified as obese

Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle