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General Population Clinical trials typically exclude patients with significant comorbidities, active mental health conditions, and medication adherence concerns

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Like you're finding that this drug initially that was intended to help the many millions of diabetes sufferers is also having an impact on general appetite and reward regulation in the brain

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11 This illustrates that regardless of the drivers of obesity, PwO are in an established state of pathological energy homeostasis that requires intensification of treatment beyond foundational lifestyle changes, and which often requires the use of anti-obesity medications (AOMs)