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In contrast, although E3 enzymes lack such pockets and the development of specific inhibitors remains challenging, with advances in bioinformatics and novel technologies including mass spectrometry and high-throughput screening, the development and success of specific E3 inhibitors might soon be within reach

Hock, Dieter Mayer, E.ds., Springer Berlin Heidelberg, Physicochemical Properties, 2013, pp 1125-1138.Reference Source Lipinski CA, Lombardo F, Dominy BW, Feeney P

Think of it this way: the medication is the context, but the stress on your system is the trigger

I'll explain what is known so far

using degraded peptides introduces uncontrolled variables that compromise data integrity