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As the first oral GLP-1 receptor agonist to demonstrate a significant reduction in cardiovascular events, the SOUL trial established oral semaglutide as an evidence-based therapy that not only improves glycaemic control but also provides meaningful cardiovascular protection for people with type 2 diabetes who are at high cardiovascular risk

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However, patients with CKD require careful monitoring, especially if experiencing severe gastrointestinal adverse effects, and should maintain adequate hydration throughout treatment

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Formulated in an oral capsule format for laboratory research focused on angiogenesis, tissue remodeling, and cellular signaling

Decreased appetite (6%) A reported 6% and 9% of patients who took 7 mg and 14 mg of Rybelsus experienced reduced appetite