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Plasmodium culture media is optimized to mimic physiological blood conditions, while Ringer is a nutrient-poor solution
For example, Mattson et al
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells
Mucosal Immunol 2 , 37 (2009)
However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC
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