Ann Intern Med 104:427429 Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L (2001) Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
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In particular, as the most redox active organelle, mitochondria contain 10-15% of total cellular GSH 9