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doi:10.1053/j.gastro.2011.08.014

What the Evidence Says The question of whether L-carnitine pills are effective for weight loss has attracted considerable research interest, though the overall evidence base remains modest and mixed

found a strong correlation between plasma MSTN levels and insulin sensitivity, and that injection of myostatin induced insulin resistance in mice (63)

Patients who escalate doses too rapidly or skip the recommended titration schedule are more likely to experience prolonged or severe gastrointestinal symptoms

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some case reports suggest a possible interaction that may affect anticoagulant activity, and closer INR monitoring may be warranted if use is considered appropriate L-carnitine supplements are not a substitute for a balanced diet or structured physical activity