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Abbreviations CINeMA: Confidence In Network Meta-Analysis EMA: European Medicines Agency FDA: US Food and Drug Administration GIP: Glucose-dependent insulinotropic peptide GLP-1 RA: Glucagon-like peptide-1 receptor agonist MD: Mean difference References Tsapas A, Avgerinos I, Karagiannis T et al (2020) Comparative effectiveness of glucose-lowering drugs for type 2 diabetes: a systematic review and network meta-analysis

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Side effects Nausea is one of the most common side effects, especially as your body adjusts to the way the medicine affects digestion

In the DUAL I trial, participants taking Xultophy required a lower average of 39 units of insulin per day, compared to 62 units for those on Tresiba alone

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So are those who take certain medications including proton-pump inhibitors