It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC
With regular use, glutathione therapy may help support: Neutralization of free radicals and reduction of oxidative stress Liver detoxification pathways and natural cleansing Immune system strength and cellular defense Skin tone, brightness, and healthy aging
BenquetC , Castaigne JP, Pham K, Robitaille M, and Frohman LA
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Geng et al
The same source also indicates that injectable B12 reliably restores levels when oral absorption is impaired