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Regarding glutamatergic signaling, a decrease in anxiety-like behaviors in 5xFAD mice older than 5 months is accompanied by an age-dependent reduction in mGluR5 binding availability in the hippocampus, striatum, cerebellum and cortex (Lee et al., 2019)

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AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

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GLP-1 drugs help people lose weight, which is important because the risks from obesity account for 40% of all cancer diagnoses in the U.S., impacting prognosis and survival

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