Overweight and obesity increase the risk of type 2 diabetes, heart disease, hypertension, and dyslipidemia, and are significant drivers of both morbidity and mortality
The direct action of GLP-1 which can also be demonstrated in the perfused pancreas, with isolated islets and with beta cell derived cell lines involves activation of the beta cell GLP-1R which couples through the heterotrimeric G-protein Gs to activate adenylyl cyclase and increase intracellular cAMP (27, 65)
Side Effects and Safety Concerns Like all prescription medicines, GLP-1s can result in side effects
Optimizing insulin absorption and insulin injection technique in older adults
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ
Deep diving into GLP-1 patient forums its clear microdosing is already common practice