Weidert K, Pleasants E, Parham L, Dolgins E, Anderson E, Prata N
Since D2HG and L2HG are indistinguishable in standard LC-MS, to determine which 2HG enantiomer(s) is affected, we adapted a chiral N-(p-toluenesulfonyl)-L-phenylalanyl chloride (TSPC) derivation followed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis 24,40
Genuine patients, who would benefit tremendously from these drugsdiabetics or obese individuals with comorbiditiesmay shun these drugs, for fear of side effects
While short-term use may improve insulin sensitivity, chronic exposure can worsen metabolic conditionsespecially in those already struggling with blood sugar control
These ions are asymmetrically distributed between luminal and abluminal membranes, of which efflux and influx were mainly dependent on the ion transporters on BBB
A total of 48 relevant studies were included