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The main concern with oral contraception and GLP-1 drugs is not harm, but effectiveness
With his efforts, there were more comprehensive basic and clinical studies on metformin
But it does mean the risk profile is different from FDA-approved versions
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The difficulty in substantiating this link partly arises from the inherent complexity of interrogating these widely-distributed systems using pharmacological approaches, compounded by observations that native GLP-1 and pharmacokinetically-optimized therapeutic GLP-1 receptor agonists (GLP-1RAs) suppress eating via divergent signalling pathways 1622