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The Numeric Pain rating scale was performed by asking patients to circle the number between 0 and 10 representing their degree of pain [29]

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Nature Reviews Endocrinology, 9 (6), 357-365

Facial flushing results from melanocortin-mediated nitric oxide release causing peripheral vasodilation the same mechanism that produces erections as a side effect of Melanotan-2

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Algorithm 778: L-BFGS-B: fortran subroutines for large-scale bound-constrained optimization