Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids
It ebbed and flowed a bit, but that was the average
Source: Barrett, et al JAMA Surgery, September 17, 2025 Researchers correlated insurance claims data and electronic medical records in a system that owns both an insurance plan (Highmark) and a provider system (Allegheny Health), and compared total medical expense for over 30,000 individuals who had either metabolic and bariatric surgery (sleeve gastrectomy) or were treated with GLP-1 medications between 2018 and 2023
The most robust data comes from Novo Nordisks large cardiovascular outcomes trial SELECT, which found semaglutide reduced CV event risk by 26% in high risk type 2 diabetics
It counteracts muscle atrophy and promotes full functional recovery, as evidenced by improved biomechanical and functional assessments in treated rats
Foods that can cause an upset stomach are best to avoid when taking metformin and Ozempic together