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higher for older adults or those at risk for sarcopenia) plus resistance training to preserve lean mass

Dual targeting of serine availability, through PHGDH inhibition and dietary restriction, represents a promising therapeutic paradigm to overcome resistance in this aggressive subtype

It was developed for diabetes management and later approved for chronic weight management at higher doses

Neither route has human clinical trial evidence

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Metformin HCl extended-release: the recommended starting dosage of metformin HCl extended-release in XIGDUO XR is 500 mg orally once daily