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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome
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Research on combination approaches remains limited, but the distinct delivery pathways suggest potential synergy
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The remaining 25 articles were included in the qualitative synthesis, and 16 in the quantitative synthesis (Figure 1)
