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doi: 10.1016/j.crohns.2012.07.010 238 RastegarpanahMMalekzadehRVahediHMohammadiMElahiEChaharmahaliMet al

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Intracellular ROS elevated by concurrent inhibition of the Nrf2 and CD44v9 pathways promotes p38 MAPK activation and modulates the expression or activity of cell cycle regulators, including cyclin D1, the cyclin-dependent kinase inhibitors (CDKI

Approximately 25 years ago, it was shown that these compounds produce their effects by blocking neurotransmission at NMDA-type glutamate receptors ( Figure 1 ), giving rise to current glutamatergic theories

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