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Mice lacking the clock activator Bmal1 in adipocytes ( Bmal1 knockout (KO)) displayed reduced mitochondrial OCR in response to pyruvate during the dark period (ZT14) compared with mice with an intact clock
10.1111/j.1464-5491.2009.02748.x 32 DAlessioD
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The body composition changes were dose-dependent and reversible after discontinuation
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