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doi: 10.1016/S0140-6736(21)00213-0 21 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al
Moreover, GLP-1RAs can reverse EndMT induced by high glucose and IL-1 via activating the AMPK pathway, which was evidenced by augmenting an endothelium marker expression (CD31), as well as alleviating mesenchymal markers expression (SM22 (sensitive 22 kDa actin-binding protein of the calponin), vimentin and Snail) [119]
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These signaling effects are central to understanding regeneration and cellular communication networks
PRP has been used for decades without demonstrated cancer promotion, providing a precedent for growth factor therapy safety
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