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Two independent controlled studies using the same dose concluded the effect was of little clinical significance and not likely to be of major therapeutic benefit. Because the negative studies matched the positive studies dose, the failure cannot be explained by underdosing
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Histopathological evidence supports these proposed mechanisms
Swelling or induration slight firmness or a small raised area may persist for several hours post-injection
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2,28,34 Moreover, stimulation of NTS GLP-1 neurons inhibits hepatic glucose production without altering peripheral glucose uptake, illustrating the involvement of the central GLP-1 system in energy homeostasis and glucose metabolism
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