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Mol Biol Cell , 13: 11091121, 2002
When intestinal epithelial cells and immune cells detect bacterial components and metabolites through pattern recognition receptors (e.g., Toll-like receptors, TLRs), they activate NADPH oxidases, resulting in ROS production (O 2 - , H 2 O 2 )
Nanoparticle modification, such as combining NAC with nintedanib-loaded chitosan, has enhanced its anti-fibrotic effect without harming normal cells [154]
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