The best way for healthy individuals to prevent a vitamin B12 overdose is to eat a well-rounded and healthy diet, incorporating foods high in B12 like organic animal meat, wild seafood, organic dairy products and eggs
In cultured human keratinocytes exposed to UVB radiation (a standard oxidative stress model), pre-treatment with 10 nM GHK-Cu resulted in: 2.8-fold increase in glutathione reductase mRNA (the enzyme regenerating reduced glutathione from its oxidized form) 2.3-fold increase in catalase expression (HO decomposition) 1.9-fold increase in ferritin heavy chain (sequestering iron, another Fenton-active metal) 62% reduction in 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, a DNA oxidative damage marker The protective effect disappeared when using copper-free GHK or copper chloride alone, confirming the intact peptide-copper complex is required
What do you make of anecdotal reports found on social media
I am not a medically trained person but I've had Pernicious Anaemia (one of many causes of B12 deficiency) for more than 46 years
A: It is studied as a growth hormone secretagogue that can increase natural GH pulses
Ethics statement The animal study was approved by this study was approved by the Animal Ethics Committee of Shahid Beheshti University (ethical code: IR.SBU.REC.1402.152)