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In fact, weight loss due to a major decline in lean body mass is normally associated with a decline in skeletal muscle mass and strength, resulting in an increased risk of sarcopenia, impaired glucose sensitivity, and poor glucose control ( The liver plays a central role in the regulation of lipid metabolism as it is the foremost site of lipid uptake, synthesis, oxidation, and distribution to peripheral tissues

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Conflicts of Interest There are no conflicts of interest

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- Seek medical care if you experience severe or persistent pain in your abdomen, chest pain, or continuous vomiting or diarrhea

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Should You Taper Off Tirzepatide

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Combining them can cause dangerously shallow breathing, extreme sleepiness, and can be fatal

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doi: 10.3389/fphar.2025.1610793 Received 12 April 2025 Accepted 21 July 2025 Published 18 August 2025 Volume 16 - 2025 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Sena Ardicli, Bursa Uluda University, Trkiye Huiwen Pang, University of Queensland, Australia Updates Copyright 2025 Zedan, El-Moslemany, Bahnasy, Eldamaty, Ibraheim, Alotaibi, Abdelmegeid, Shukry and Elolimy

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