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Interestingly, few studies evaluated the fluorescent dye leaching of particles under conditions such as simulated gastric and intestinal fluids, and fluorescence leaching was negligible [23, 52]

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GHK-Cu is a photolabile copper(II) complex, and freeze-thaw cycling can disrupt the copper coordination sphere independently of any degradation of the peptide backbone, which means cumulative in-use exposure is a real variable and not a generic caution

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I switched because I know sometimes being on the same formula of probiotics for a long time can make them less effective