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The form of the activation was derived by nonlinear regression on the data in [23, 24]

The ammonium group of ipratropium is similarly positioned to where the ammonium group of carnitine is in the occluded conformation, and forms cation- interactions with the aforementioned hydrophobic residues

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This method achieves significantly higher plasma concentrations compared to oral supplements, which typically have only 2-10% absorption rates.