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The semaglutide and cagrilintide mix produced superior gains in waist circumference (average reduction of 15-17 cm), blood pressure (systolic BP reduced by 8-10 mmHg), lipid profiles (triglycerides reduced by 20-25%, HDL increased by 10-15%), glycemic control in diabetic participants (HbA1c reduced by 1.5-2.0%), and swelling markers (CRP reduced by 40-50%)

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The amylin-mediated slowing of gastric emptying involves start of receptors in the area postrema that send signals through the vagus nerve to block gastric motility