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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC

The quality of the GH pulse differs: Ipamorelins selectivity means the GH signal is less contaminated by the hormonal milieu changes (cortisol, prolactin) that accompany GHRP-6, potentially making downstream IGF-1 and metabolic readouts cleaner research endpoints

10.3109/09513590.2012.650768 127 WangY.LiD.XuX.QianR.ZhangY.HuangY.et al (2016)

DHT is a hormone that derives from testosterone and has links with hair loss, Study limitations: The sample size was small and the study only measured DHT levels, not actual hair loss

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The IGF-1 axis benefits from the same pause: it drifts back toward baseline instead of sitting chronically elevated, which is the safer position given GH/IGF-1s growth-promoting signaling