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Class III FINs such as FIN56 act by indirect inhibiting and inactivating GPX4 via the squalene synthase-mevalonate pathway, which participates in the mitochondrial electron transport chain and also functions as endogenous lipophilic antioxidants [40, 108]
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Low glutathione appears in conditions of accelerated aging like diabetes and metabolic syndrome [20]
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BPC-157, in particular, has demonstrated protective effects against NSAID-induced gastric damage and may act on nitric oxide pathways to maintain vascular homeostasis
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