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Experimental evaluations demonstrated that the metal complex could efficiently catalyze the oxidation of glutathione (GSH) into glutathione disulfide (GSSG)
N Engl J Med 384(11):9891002
L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell
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There were no hepatic safety concerns identified in the completed trials
Briefly, cells were washed with PBS and changed to media with no serum + 50 g/mL cycloheximide to inhibit protein synthesis for 1 hour, then stimulated with vehicle or 100 nM exendin-4 in reverse time order for 8, 6, 4, 2 and 1 hours
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