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P values indicated, calculated by two-way ANOVA with Tukeys ( a ) or dks multiple comparisons test ( b,c ), and one-way ANOVA with Dunnetts multiple comparisons test ( d )

It stimulates blood vessel and nerve outgrowth and increases collagen, elastin, and glycosaminoglycan synthesis

The route of administration can significantly impact a compound's bioavailability and efficacy

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