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Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions

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Due to the increase in use, science may need time to catch up on the side effects as in, to determine both short-term and long-term side effects as the drugs are used for different conditions and for longer periods of time

Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

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Side effects should never be debilitating