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Apoptosis of bovine aortic cells exposed to DOX was accompanied by a significant increase in cellular iron uptake and activation of iron regulatory protein 1, the latter mediated by the transferrin receptor

et al., 2022

Notably, AOD9604 did not act as a direct 3-AR ligand in prior receptor assays, suggesting alternative signaling mechanisms are at play

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However, due to c-MYCs unique properties with respect to a lack of a defined three-dimensional structure, nuclear localization and absence of a targetable enzymatic pocket, targeting c-MYC for cancer treatment has presented a challenge