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The major difference is molecular structure: orforglipron is a non-peptide small molecule that survives digestion, while semaglutide is peptide-based and requires injection

Ozempic (injection) and Rybelsus (tablet) are FDA-approved to treat type 2 diabetes, and Wegovy is approved for weight loss

When you swallow a vitamin pill, it has to survive a gauntlet of obstacles before it reaches your bloodstream