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Statistical methods CV risk prediction model As described previously, an identical 3-point composite MACE endpoint was the primary outcome for the LEADER, SUSTAIN 6 and PIONEER 6 CVOTs, and was defined as time to first occurrence of death from CV disease (CVD, including undetermined causes), non-fatal MI or non-fatal stroke [13, 26, 31]

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes

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